Description
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Pirfesca® Scar Gel (Pirfenidone Gel)
Quick ID table
| Item | Details |
|---|---|
| Product name | Pirfesca® Scar Gel |
| Primary purpose | Supports the appearance of raised scars (hypertrophic and keloid) |
| Texture | Lightweight, fast-absorbing gel |
| Net quantity | 30 g per tube |
| Manufacturer | Cipla Ltd. |
| Use | External use only |
| Notes on testing | Dermatologically tested |
What it’s for
| Scar type | What “raised” means | What the gel aims to improve |
|---|---|---|
| Hypertrophic scars | Thick, raised scar that stays within the wound borders | Texture, thickness, firmness, overall appearance |
| Keloid scars | Raised scar that can grow beyond the wound borders | Texture, thickness, visible prominence, comfort/hydration |
How it works (biology → product intent)
| What’s happening in raised scars | Key drivers | What Pirfesca aims to do |
|---|---|---|
| Wound healing signals stay “on” too long | Pro-fibrotic signaling (notably TGF-β) and inflammatory cytokines | Dial down pro-fibrotic signaling and calm the “over-healing” response |
| Fibroblasts shift into high-output repair mode | Myofibroblast features (e.g., α-SMA), fibroblast proliferation | Reduce fibroblast overactivity and myofibroblast-like behavior |
| Excess collagen and extracellular matrix accumulate | Increased collagen/ECM production and organization | Reduce collagen/ECM buildup linked to thickness and firmness |
Mechanism overview (pirfenidone)
| Mechanistic effect described | Why it matters for raised scars |
|---|---|
| Reduces pro-fibrotic cytokine signaling (including TGF-β–linked pathways) | Targets signaling associated with excess collagen deposition |
| Slows fibroblast proliferation | Helps reduce ongoing scar “build” activity |
| Reduces myofibroblast features (e.g., α-SMA) | May decrease contractile, thickened scar architecture |
| Decreases collagen/ECM production and organization | Maps to improvements in firmness, thickness, and texture over time |
Key ingredients
Active ingredient
| Ingredient | Role |
|---|---|
| Pirfenidone | Anti-fibrotic and anti-inflammatory activity intended to reduce collagen buildup and improve scar texture/appearance over time |
Base ingredients
| Ingredient | Function |
|---|---|
| Purified Water | Solvent and hydration base |
| Diethylene Glycol Monoethyl Ether | Enhances skin penetration of the active |
| Polyacrylate Crosspolymer-6 | Gel structure and smooth feel |
| Methylparaben | Preservative to limit microbial growth |
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